Anticorps Recombinant de lapin anti-TDO2

TDO2 Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

240068C2

N° de cat : 83236-2-PBS

Synonymes

240068C2, EC:1.13.11.11, TDO, TO, TPH2

---

Galerie de données de validation

• 

  WB analysis of rat liver using 83236-2-RR (same clone as 83236-2-PBS)

  rat liver tissue were subjected to SDS PAGE followed by western blot with 83236-2-RR (TDO2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83236-2-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 83236-2-RR

  Biolayer interferometry (BLl) kinetic assays of 83236-2-RR against Human TDO2 were performed. The affinity constant is below 1 pM.

---

Informations sur le produit

83236-2-PBS cible TDO2 dans les applications de WB, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TDO2 Protéine recombinante Ag8531
• Nom complet: tryptophan 2,3-dioxygenase
• Masse moléculaire calculée: 406 aa, 48 kDa
• Poids moléculaire observé: 40-50 kDa
• Numéro d’acquisition GenBank: BC005355
• Symbole du gène: TDO2
• Identification du gène (NCBI): 6999
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TDO2 (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 are three enzymes that catalyze the amino acid tryptophan into kynurenine in the kynurenine pathway (PMID: 23090118, 28469468). TDO2 plays an important role in neurological diseases such as Alzheimer's disease, Parkinson's disease and autism. Overexpression of TDO2 promoted tumor cell survival and was correlated with tumor grade and poor prognosis in triple negative breast cancer, brain tumors and esophageal squamous cell carcinoma. TDO2 may be a potential therapeutic target in some cancers. (PMID: 21976023, 30134247)

{{ptg:RelatedPrimaryAntibodies}}