Anticorps Monoclonal anti-TERF2

TERF2 Monoclonal Antibody for WB, ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat, souris

Applications

WB, ChIP, ELISA

Conjugaison

Non conjugué

Publications(5)

CloneNo.

5B1E1

N° de cat : 66893-1-Ig

Synonymes

5B1E1, Telomeric DNA-binding protein, Telomeric repeat-binding factor 2, TRBF2, TRF2



Applications testées

Résultats positifs en WBcellules Jurkat, cellules 4T1, cellules Daudi, cellules HEK-293, cellules HSC-T6, cellules HT-29, cellules K-562, cellules MCF-7, cellules NIH/3T3

Dilution recommandée

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

66893-1-Ig cible TERF2 dans les applications de WB, ChIP, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Réactivité citéeHumain, souris
Hôte / Isotype Mouse / IgG1
Clonalité Monoclonal
Type Anticorps
Immunogène TERF2 Protéine recombinante Ag28513
Nom complet telomeric repeat binding factor 2
Masse moléculaire calculée 56 kDa
Poids moléculaire observé 60-65.32-35 kDa
Numéro d’acquisition GenBankBC024890
Symbole du gène TERF2
Identification du gène (NCBI) 7014
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine G
Tampon de stockage PBS with 0.02% sodium azide and 50% glycerol
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

TERF2, also named as TRF2 and Telomeric repeat-binding factor 2, is a 542 amino acid protein, which contains 1 HTH myb-type DNA-binding domain and localizes in the Nucleus. TRF2 binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. TERF2 is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. TERF2 together with DCLRE1B/Apollo, is required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B), which is needed for telomere replication during fork passage and prevent aberrant telomere topology. TERF2 recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length. TERF2 exists some isoforms with MV 60 kDa and 32 kDa.

Protocole

Product Specific Protocols
WB protocol for TERF2 antibody 66893-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
human

Sci Adv

Regulation of telomere homeostasis and genomic stability in cancer by N 6-adenosine methylation (m6A).

Authors - Ji Hoon Lee
mouse,humanWB

Front Pharmacol

Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.

Authors - Xiaoyu Qi
humanWB,ChIP

Nat Commun

Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence

Authors - Athanasios Siametis
mouseWB

Acta Biochim Biophys Sin (Shanghai)

miR-29b-1-5p exacerbates myocardial injury induced by sepsis in a mouse model by targeting TERF2

Authors - Yaqing Jiang
mouseWB

Exp Mol Med

SUMOylation of TP53INP1 is involved in miR-30a-5p-regulated heart senescence

Authors - Yi-Xiang Hong

Avis

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.


FH

Refik (Verified Customer) (08-26-2025)

Antibody works well when prepared at 1:5000 dilution in 5% BSA and overnight primary incubation for Western Blot with 1:300 secondary antibody and 1:500 dilution using 5% Donkey Serum for ICC/IHC for overnight incubation with 1:400 secondary (2 hours at rtp) and 1:10000 DAPI for nuclei.

  • Applications: Western Blot, Immunofluorescence
  • Primary Antibody Dilution: 1:5000 for Western Blot and 1:500 for ICC/IHC for both human-derived cells
  • Cell Tissue Type: Human cardiac cells
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