Anticorps Recombinant de lapin anti-TGF beta 1

TGF beta 1 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250119E2

N° de cat : 98506-5-PBS

Synonymes

TGFB1, TGFB1,TGF beta 1,TGFbeta,TGF-beta 1, TGF-beta1, Latency-associated peptide, TGF beta

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Galerie de données de validation

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  FC experiment of human PBMCs using 98506-5-RR (same clone as 98506-5-PBS)

  1x10^6 untreated or anti-CD3/CD28 treated human PBMCs were surface stained with 0.25 ug Anti-Human TGF beta 1 Rabbit RecAb (98506-5-RR, Clone: 250119E2) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then fixed and stained with Anti-Human Foxp3. CD4+ cells were pre-gated for analysis. This data was developed using the same antibody clone with 98506-5-PBS in a different storage buffer formulation.

• 

  FC experiment of human PBMCs using 98506-5-RR (same clone as 98506-5-PBS)

  1x10^6 anti-CD3/CD28 treated human PBMCs were surface stained with 0.25 ug Anti-Human TGFB1 Rabbit RecAb (98506-5-RR, Clone: 250119E2) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated human PBMCs were surface stained with 0.25 ug Anti-Human TGFB1 Rabbit RecAb (98506-5-RR, Clone: 250119E2) (black, dashed) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). CD4+ cells were pre-gated for analysis. Cells were not fixed. This data was developed using the same antibody clone with 98506-5-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98506-5-RR

  Biolayer interferometry (BLl) kinetic assays of 98506-5-RR against Human TGF beta 1 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

98506-5-PBS cible TGF beta 1 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TGF beta 1 Protéine recombinante Eg0879
• Nom complet: transforming growth factor, beta 1
• Masse moléculaire calculée: 44 kDa
• Symbole du gène: TGFB1
• Identification du gène (NCBI): 7040
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

TGF Beta 1 (TGF-β1) is a pleiotropic cytokine and a member of the TGF-β superfamily (including TGF-β1, TGF-β2, and TGF-β3). It is encoded by the TGFB1 gene and acts as a secreted protein involved in controlling cell growth, proliferation, differentiation, and apoptosis. TGF-β1 is produced by various cell types (e.g., platelets, lymphocytes, macrophages, epithelial cells, and inflammatory cells) and is secreted as a precursor requiring proteolytic activation to yield the mature, biologically active peptide. TGF-β1 plays crucial roles in immune regulation, wound healing, fibrosis, and tissue remodeling (including cardiac injury and fibrosis). It also influences cancer progression by promoting epithelial-to-mesenchymal transition (EMT) and metastasis in tumors.

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