• Phare
  • Validé par KD/KO

Anticorps Polyclonal de lapin anti-TGFBR3-Specific

TGFBR3-Specific Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, IHC, IF, ELISA

Conjugaison

Non conjugué

Publications(8)

N° de cat : 20000-1-AP

Synonymes

TGFBR3, betaglycan, BGCAN, TGF beta receptor type 3, TGF beta receptor type III



Applications testées

Résultats positifs en WBcellules A549, cellules A431

Dilution recommandée

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

20000-1-AP cible TGFBR3-Specific dans les applications de WB, IHC, IF, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Réactivité citéeChèvre, Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet transforming growth factor, beta receptor III
Masse moléculaire calculée 93 kDa
Poids moléculaire observé 110-150 kDa
Numéro d’acquisition GenBankNM_003243
Symbole du gène TGFBR3
Identification du gène (NCBI) 7049
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS with 0.02% sodium azide and 50% glycerol
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Transforming growth factor β (TGF-β) is a multifunctional cytokine that plays important roles in normal development and homeostasis (PMID: 8530052). There are three TGF-β forms: TGF-β1, TGF-β2, and TGF-β3. The diverse effects of TGF-β are mediated by the TGF-β receptors and cell surface-binding proteins. Three TGF-beta receptors exist: TGFBR1, TFGBR2, TGFBR3 (PMID: 8530052; 30184463). TGFBR3, also known as betaglycan, is a transmembrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. In addition to the transmembrane form, the extracellular domain of TGFBR3 can be cleaved to a soluble form (sTGFBR3), which may serve as an antagonist of TGF-β to inhibit TGF-β signaling (PMID: 30184463). TGFBR3 has a larger apparent molecular weight than the calculated molecular weight, due to extensive carbohydrate modifications (PMID: 1556106). This antibody is specific to TGFBR3.

Protocole

Product Specific Protocols
WB protocol for TGFBR3-Specific antibody 20000-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB,IF

Cancer Res

Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway.

Authors - Li-Yuan Yu-Lee
  • KD Validated
goatIHC

Cell Prolif

Spatially multicellular variability of intervertebral disc degeneration by comparative single-cell analysis

Authors - Peng Lin
mouse

Int Immunopharmacol

Vitamin D3 alleviates pulmonary fibrosis by regulating the MAPK pathway via targeting PSAT1 expression in vivo and in vitro.

Authors - Wenxiang Zhu
humanWB

Mol Cell Endocrinol

The miR-103a-3p/TGFBR3 axis regulates TGF-β-induced orbital fibroblast activation and fibrosis in thyroid-eye disease

Authors - Bingyu Xie
  • KD Validated
human

bioRxiv

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

Authors - Kartik Bhamidipati
mouseWB

Redox Biol

FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway

Authors - Limin Shi

Avis

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.


FH

Kenzo (Verified Customer) (08-15-2023)

This antibody worked well for labeling TGF beta receptor type 3 in mouse kidney. I was able to acquire robust immunofluorescence signals with the antibody and highly recommend this KO validated antibody.

  • Applications: Immunofluorescence
  • Primary Antibody Dilution: 1:200
  • Cell Tissue Type: Mouse kidney
FH

Manfred (Verified Customer) (05-09-2022)

I highly recommend this anitbody. Protein of interest was detected at 94kDa.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:1000
  • Cell Tissue Type: PBMCs
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