- Phare
- Validé par KD/KO
Anticorps Polyclonal de lapin anti-TGFBR3-Specific
TGFBR3-Specific Polyclonal Antibody for WB, ELISA
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain et plus (2)
Applications
WB, IHC, IF, ELISA
Conjugaison
Non conjugué
N° de cat : 20000-1-AP
Synonymes
Galerie de données de validation
Applications testées
| Résultats positifs en WB | cellules A549, cellules A431 |
Dilution recommandée
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Applications publiées
| KD/KO | See 2 publications below |
| WB | See 5 publications below |
| IHC | See 2 publications below |
| IF | See 1 publications below |
Informations sur le produit
20000-1-AP cible TGFBR3-Specific dans les applications de WB, IHC, IF, ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Réactivité citée | Chèvre, Humain, souris |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Polyclonal |
| Type | Anticorps |
| Immunogène | Peptide |
| Nom complet | transforming growth factor, beta receptor III |
| Masse moléculaire calculée | 93 kDa |
| Poids moléculaire observé | 110-150 kDa |
| Numéro d’acquisition GenBank | NM_003243 |
| Symbole du gène | TGFBR3 |
| Identification du gène (NCBI) | 7049 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par affinité contre l'antigène |
| Tampon de stockage | PBS with 0.02% sodium azide and 50% glycerol |
| Conditions de stockage | Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA. |
Informations générales
Transforming growth factor β (TGF-β) is a multifunctional cytokine that plays important roles in normal development and homeostasis (PMID: 8530052). There are three TGF-β forms: TGF-β1, TGF-β2, and TGF-β3. The diverse effects of TGF-β are mediated by the TGF-β receptors and cell surface-binding proteins. Three TGF-beta receptors exist: TGFBR1, TFGBR2, TGFBR3 (PMID: 8530052; 30184463). TGFBR3, also known as betaglycan, is a transmembrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. In addition to the transmembrane form, the extracellular domain of TGFBR3 can be cleaved to a soluble form (sTGFBR3), which may serve as an antagonist of TGF-β to inhibit TGF-β signaling (PMID: 30184463). TGFBR3 has a larger apparent molecular weight than the calculated molecular weight, due to extensive carbohydrate modifications (PMID: 1556106). This antibody is specific to TGFBR3.
Protocole
| Product Specific Protocols | |
|---|---|
| WB protocol for TGFBR3-Specific antibody 20000-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Cancer Res Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway.
| ||
Cell Prolif Spatially multicellular variability of intervertebral disc degeneration by comparative single-cell analysis | ||
Int Immunopharmacol Vitamin D3 alleviates pulmonary fibrosis by regulating the MAPK pathway via targeting PSAT1 expression in vivo and in vitro. | ||
Mol Cell Endocrinol The miR-103a-3p/TGFBR3 axis regulates TGF-β-induced orbital fibroblast activation and fibrosis in thyroid-eye disease
| ||
bioRxiv Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis | ||
Redox Biol FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway |
Avis
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
FH Kenzo (Verified Customer) (08-15-2023) | This antibody worked well for labeling TGF beta receptor type 3 in mouse kidney. I was able to acquire robust immunofluorescence signals with the antibody and highly recommend this KO validated antibody.
|
FH Manfred (Verified Customer) (05-09-2022) | I highly recommend this anitbody. Protein of interest was detected at 94kDa.
|

