Anticorps Polyclonal de lapin anti-TGFBR3-Specific

• Phare
• Validé par KD/KO

TGFBR3-Specific Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20000-1-PBS

Synonymes

TGFBR3, betaglycan, BGCAN, TGF beta receptor type 3, TGF beta receptor type III

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Galerie de données de validation

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  WB analysis of A549 using 20000-1-AP (same clone as 20000-1-PBS)

  A549 cells were subjected to SDS PAGE followed by western blot with 20000-1-AP (TGFBR3-Specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20000-1-PBS in a different storage buffer formulation.

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  WB analysis of A431 using 20000-1-AP (same clone as 20000-1-PBS)

  A431 cells were subjected to SDS PAGE followed by western blot with 20000-1-AP (TGFBR3-Specific antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20000-1-PBS in a different storage buffer formulation.

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Informations sur le produit

20000-1-PBS cible TGFBR3-Specific dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: transforming growth factor, beta receptor III
• Masse moléculaire calculée: 93 kDa
• Poids moléculaire observé: 110-150 kDa
• Numéro d’acquisition GenBank: NM_003243
• Symbole du gène: TGFBR3
• Identification du gène (NCBI): 7049
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Transforming growth factor β (TGF-β) is a multifunctional cytokine that plays important roles in normal development and homeostasis (PMID: 8530052). There are three TGF-β forms: TGF-β1, TGF-β2, and TGF-β3. The diverse effects of TGF-β are mediated by the TGF-β receptors and cell surface-binding proteins. Three TGF-beta receptors exist: TGFBR1, TFGBR2, TGFBR3 (PMID: 8530052; 30184463). TGFBR3, also known as betaglycan, is a transmembrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. In addition to the transmembrane form, the extracellular domain of TGFBR3 can be cleaved to a soluble form (sTGFBR3), which may serve as an antagonist of TGF-β to inhibit TGF-β signaling (PMID: 30184463). TGFBR3 has a larger apparent molecular weight than the calculated molecular weight, due to extensive carbohydrate modifications (PMID: 1556106). This antibody is specific to TGFBR3.

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