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Anticorps Polyclonal de lapin anti-TGM3

TGM3 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 21406-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of various lysates using TGM3 Polyclonal antibody (21406-1-AP)

    WB analysis using 21406-1-AP (same clone as 21406-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21406-1-AP (TGM3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21406-1-PBS in a different storage buffer formulation.

Informations sur le produit

21406-1-PBS cible TGM3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène TGM3 Protéine recombinante Ag16131
Nom complet transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Masse moléculaire calculée 693 aa, 77 kDa
Poids moléculaire observé77 kDa; 30-35 kDa; 44-50 kDa
Numéro d’acquisition GenBankBC109076
Symbole du gène TGM3
Identification du gène (NCBI) 7053
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TGM3 (Transglutaminase 3) is a Protein Coding gene. Diseases associated with TGM3 include Uncombable Hair Syndrome 2 and Uncombable Hair Syndrome 1. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. TG3 is expressed as an inactive 77 kDa zymogen which must be activated by limited proteolytic processing into two fragments (44 kDa and 30 kDa) of which the larger, N-terminal fragment carries the catalytic activity (PMID: 35328331).

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