Anticorps Recombinant de lapin anti-KIM-1/HAVCR1

KIM-1/HAVCR1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242001D1

N° de cat : 84600-5-PBS

Synonymes

HAVCR1, KIM-1, TIM-1, 242001D1, CD365

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Galerie de données de validation

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  WB analysis of HuH-7 using 84600-5-RR (same clone as 84600-5-PBS)

  HuH-7 cells were subjected to SDS PAGE followed by western blot with 84600-5-RR (TIM-1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84600-5-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84600-5-RR

  Biolayer interferometry (BLl) kinetic assays of 84600-5-RR against Human TIM-1 were performed. The affinity constant is 0.314 nM.

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Informations sur le produit

84600-5-PBS cible KIM-1/HAVCR1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: KIM-1/HAVCR1 Protéine recombinante Eg1442
• Nom complet: hepatitis A virus cellular receptor 1
• Masse moléculaire calculée: 39kDa
• Poids moléculaire observé: 100 kDa
• Numéro d’acquisition GenBank: NM_001173393.3
• Symbole du gène: HAVCR1
• Identification du gène (NCBI): 26762
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TIM-1, also known as kidney injury molecule (KIM-1), was first identified as a marker of acute kidney injury. TIM-1 mRNA and protein dramatically increase after ischemic kidney injury while there are low levels in normal kidneys. In addition, TIM-1 is expressed on CD4+ T cells after activation and its expression was sustained preferentially in Th2 but not Th1 cells. However, TIM-1 is expressed on both Th1 and Th2 cells and TIM-1 blockade prolongs survival of fully MHC-mismatched cardiac transplants. TIM-4, expressed by macrophages, is the ligand for TIM-1, and TIM-1 - TIM-4 interactions regulate Th cell responses and modulate Th1/Th2 cytokine balance. Moreover, TIM-1 can regulate macrophage activation and alter the co-stimulatory properties of macrophages. (PMID: 20091883)

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