Anticorps Recombinant de lapin anti-TIM4

TIM4 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242616C10

N° de cat : 98401-1-PBS

Synonymes

SMUCKLER, Spleen, mucin-containing, knockout of lymphotoxin protein, T-cell immunoglobulin and mucin domain-containing protein 4, T-cell immunoglobulin mucin receptor 4, T-cell membrane protein 4

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Galerie de données de validation

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  FC experiment of mouse peritoneal macrophages using 98401-1-RR (same clone as 98401-1-PBS)

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug Anti-Mouse TIM4 Rabbit RecAb (98401-1-RR, Clone: 242616C10) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-conjugated Goat Anti-Rabbit IgG. Cells were co-stained with CoraLite® Plus 647 Anti-Mouse F4/80. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98401-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse peritoneal macrophages using 98401-1-RR (same clone as 98401-1-PBS)

  1x10^6 mouse peritoneal macrophages were surface stained with 0.25 ug Anti-Mouse TIM4 Rabbit RecAb (98401-1-RR, Clone: 242616C10) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98401-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98401-1-PBS cible TIM4 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TIM4 Protéine recombinante Eg3307
• Nom complet: T-cell immunoglobulin and mucin domain containing 4
• Masse moléculaire calculée: 38 kDa
• Numéro d’acquisition GenBank: NM_178759
• Symbole du gène: TIM4
• Identification du gène (NCBI): 276891
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

T cell immunoglobulin mucin 4 (TIM4) is a macrophage receptor for phosphatidylserine (PtdSer) on apoptotic cells. It is evidenced that TIM4 as phosphatidylserine (PS) receptor is capable of maintaining peritoneal macrophages' homeostatic function and regulating adaptive immunity based on the alteration of Ag-particular T cells' clearance. It is noteworthy that TIM4's dysregulating process was identified under several autoimmune states, in particular inside immune cells. In addition, TIM4 was identified to be over-expressed in Systemic lupus erythematosus (SLE) cases.

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