Anticorps Recombinant de lapin anti-TLE3

TLE3 Recombinant Antibody for IF/ICC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IF/ICC, ELISA

Conjugaison

Non conjugué

CloneNo.

240680G3

N° de cat : 83955-4-PBS

Synonymes

GRG3, GRG 3, ESG3, ESG, Enhancer of split groucho-like protein 3

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Galerie de données de validation

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  IF Staining of HepG2 using 83955-4-RR (same clone as 83955-4-PBS)

  Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using TLE3 antibody (83955-4-RR, Clone: 240680G3 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 83955-4-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 83955-4-RR

  Biolayer interferometry (BLl) kinetic assays of 83955-4-RR against Human TLE3 were performed. The affinity constant is 0.134 nM.

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Informations sur le produit

83955-4-PBS cible TLE3 dans les applications de IF/ICC, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TLE3 Protéine recombinante Ag1930
• Nom complet: transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
• Masse moléculaire calculée: 772 aa, 83 kDa
• Numéro d’acquisition GenBank: BC015729
• Symbole du gène: TLE3
• Identification du gène (NCBI): 7090
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TLE3, also named as KIAA1547 and ESG3, belongs to the WD repeat Groucho/TLE family. It is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas. It is a candidate biomarker of response to taxane

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