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Anticorps Recombinant de lapin anti-TLR6

TLR6 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241926A1

N° de cat : 84811-1-PBS

Synonymes

241926A1, CD286, toll like receptor 6, Toll-like receptor 6

Galerie de données de validation

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  • Western Blot (WB) analysis of mouse brain tissue using TLR6 Recombinant antibody (84811-1-RR)

    WB analysis of mouse brain using 84811-1-RR (same clone as 84811-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 84811-1-RR (TLR6 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84811-1-PBS in a different storage buffer formulation.

Informations sur le produit

84811-1-PBS cible TLR6 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Peptide
Nom complet toll-like receptor 6
Masse moléculaire calculée 480 aa, 56 kDa
Poids moléculaire observé100 kDa
Numéro d’acquisition GenBankBC111755
Symbole du gène TLR6
Identification du gène (NCBI) 10333
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TLR6, also known as CD286, belongs to the Toll-like receptor (TLR) family which is important in the innate immune response to pathogens. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. TLR6 can form a heterodimer with TLR2. TLR6 and TLR2 are both recruited to the macrophage phagosome, where they recognize peptidoglycan, a Gram-positive pathogen component (PMID: 11095740). TLR6 interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers an inflammatory response.

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