Anticorps Polyclonal de lapin anti-TLR9

TLR9 Polyclonal Antibody for IP, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (1)

Applications

WB, IP, ELISA

Conjugaison

Non conjugué

Publications(1)

N° de cat : 17230-1-AP

Synonymes

CD289, toll like receptor 9, Toll-like receptor 9, UNQ5798/PRO19605



Applications testées

Résultats positifs en IPcellules Raji,

Dilution recommandée

ApplicationDilution
Immunoprécipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

WBSee 1 publications below

Informations sur le produit

17230-1-AP cible TLR9 dans les applications de WB, IP, ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Réactivité citéerat
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène TLR9 Protéine recombinante Ag11071
Nom complet toll-like receptor 9
Masse moléculaire calculée 1032 aa, 116 kDa
Poids moléculaire observé 120 kDa, 60 kDa
Numéro d’acquisition GenBankBC032713
Symbole du gène TLR9
Identification du gène (NCBI) 54106
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS with 0.02% sodium azide and 50% glycerol
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

TLR9, also known as CD289, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. TLR9 is a nucleotide-sensing TLR that is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PMID:14716310). Upon CpG stimulation, it induces B-cell proliferation, activation, survival, and antibody production (PMID:23857366). TLR9 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response (PMID:11564765, 17932028).

Protocole

Product Specific Protocols
IP protocol for TLR9 antibody 17230-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
ratWB

Mol Cell Endocrinol

Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats.

Authors - Dongmin Li
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