Anticorps Monoclonal anti-TMEM106B

• Phare
• Validé par KD/KO

TMEM106B Monoclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

5D1F8

N° de cat : 60333-1-PBS

Synonymes

TMEM106B (1-46aa), 5D1F8, Transmembrane protein 106B

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Galerie de données de validation

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  WB analysis using 60333-1-Ig (same clone as 60333-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 60333-1-Ig (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 60333-1-Ig (same clone as 60333-1-PBS)

  WB result of TMEM106B antibody (60333-1-Ig; 1:2000; room temperature for 1.5 hours) with wild-type and TMEM106B knockout HeLa cells. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HeLa using 60333-1-Ig (same clone as 60333-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 60333-1-Ig (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 60333-1-Ig (same clone as 60333-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 60333-1-Ig (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

• 

  IP experiment of HeLa using 60333-1-Ig (same clone as 60333-1-PBS)

  IP result of anti-TMEM106B (IP:60333-1-Ig, 5ug; Detection:60333-1-Ig 1:500) with HeLa cells lysate 1720 ug. This data was developed using the same antibody clone with 60333-1-PBS in a different storage buffer formulation.

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Informations sur le produit

60333-1-PBS cible TMEM106B dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: TMEM106B Protéine recombinante Ag21448
• Nom complet: transmembrane protein 106B
• Masse moléculaire calculée: 31 kDa
• Poids moléculaire observé: ~40 kDa
• Numéro d’acquisition GenBank: BC033901
• Symbole du gène: TMEM106B
• Identification du gène (NCBI): 54664
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression.

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