Anticorps Recombinant de lapin anti-TMEM106B

TMEM106B Recombinant Antibody for WB, IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

CloneNo.

241185F10

N° de cat : 84196-2-PBS

Synonymes

241185F10, Transmembrane protein 106B

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Galerie de données de validation

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  WB analysis using 84196-2-RR (same clone as 84196-2-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84196-2-RR (TMEM106B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84196-2-PBS in a different storage buffer formulation.

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  IHC staining of mouse cerebellum using 84196-2-RR (same clone as 84196-2-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 84196-2-RR (TMEM106B antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84196-2-PBS in a different storage buffer formulation.

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  IHC staining of mouse cerebellum using 84196-2-RR (same clone as 84196-2-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 84196-2-RR (TMEM106B antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84196-2-PBS in a different storage buffer formulation.

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Informations sur le produit

84196-2-PBS cible TMEM106B dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: transmembrane protein 106B
• Masse moléculaire calculée: 31 kDa
• Poids moléculaire observé: 35 kDa
• Numéro d’acquisition GenBank: BC033901
• Symbole du gène: TMEM106B
• Identification du gène (NCBI): 54664
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TMEM106B is a genetic risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). Amyotrophic lateral sclerosis (ALS), like FTLD-TDP, is characterized by pathological TDP-43 inclusions. TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. TMEM106B can be showed as 31-55 kDa and 70-90 kDa (Glycosylated or Dimer) form in western blot test. (PMID: 27543298, 22895706, PMID: 23136129).

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