Anticorps Polyclonal de lapin anti-TMEM41B

• Phare
• Validé par KD/KO

TMEM41B Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29270-1-PBS

Synonymes

Transmembrane protein 41B, KIAA0033

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Galerie de données de validation

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  WB analysis of HeLa using 29270-1-AP (same clone as 29270-1-PBS)

  WB result of TMEM41B antibody (29270-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TMEM41B transfected HeLa cells. This data was developed using the same antibody clone with 29270-1-PBS in a different storage buffer formulation.

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  WB analysis using 29270-1-AP (same clone as 29270-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29270-1-AP (TMEM41B antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29270-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse lung using 29270-1-AP (same clone as 29270-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 29270-1-AP (TMEM41B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29270-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse lung using 29270-1-AP (same clone as 29270-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 29270-1-AP (TMEM41B antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29270-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse testis using 29270-1-AP (same clone as 29270-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 29270-1-AP (TMEM41B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29270-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse testis using 29270-1-AP (same clone as 29270-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 29270-1-AP (TMEM41B antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29270-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lung using 29270-1-AP (same clone as 29270-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 29270-1-AP (TMEM41B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29270-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human lung using 29270-1-AP (same clone as 29270-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung tissue slide using 29270-1-AP (TMEM41B antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29270-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29270-1-PBS cible TMEM41B dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TMEM41B Protéine recombinante Ag30810
• Nom complet: transmembrane protein 41B
• Masse moléculaire calculée: 32 kDa
• Poids moléculaire observé: 22-28 kDa
• Numéro d’acquisition GenBank: BC035034
• Symbole du gène: TMEM41B
• Identification du gène (NCBI): 440026
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Transmembrane protein 41B (TMEM41B), also known as Stasimon, is a major target of survival motor neuron (SMN)-dependent U12 splicing and has been identified as a protein required for motor circuit function (PMID: 23063131). TMEM41B localizes to the endoplasmic reticulum. It is involved in autophagosome biogenesis and lipid mobilization (PMID: 30126924). TMEM41B has been shown to be essential for mouse embryonic development (PMID: 30352685). Additionally, genome-scale CRISPR knockout screens reveal that TMEM41B is required for infection of flavivirus and coronavirus, including SARS-CoV-2 (PMID: 33052348; 33052332). Alternative splicing results in three transcript variants encoding distinct isoforms.

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