Anticorps Polyclonal de lapin anti-TMEM66

TMEM66 Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29599-1-PBS

Synonymes

SARAF, FOAP 7, HBV XAg-transactivated protein 3, HBV X-transactivated gene 3 protein, HSPC035

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Galerie de données de validation

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  IHC staining of mouse pancreas using 29599-1-AP (same clone as 29599-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using 29599-1-AP (TMEM66 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29599-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse cerebellum using 29599-1-AP (same clone as 29599-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 29599-1-AP (TMEM66 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29599-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse pancreas using 29599-1-AP (same clone as 29599-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using 29599-1-AP (TMEM66 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29599-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29599-1-PBS cible TMEM66 dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TMEM66 Protéine recombinante Ag29388
• Nom complet: transmembrane protein 66
• Masse moléculaire calculée: 339 aa, 37 kDa
• Numéro d’acquisition GenBank: BC015012
• Symbole du gène: TMEM66
• Identification du gène (NCBI): 51669
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TMEM66/SOCE-associated regulatory factor (SARAF) is an endoplasmic reticulum (ER)-resident transmembrane protein that promotes SOCE inactivation and prevents Ca2+ overfilling of the cell. TMEM66 plays a key role in shaping cytosolic Ca2+ signals and determining the content of the major intracellular Ca2+ stores, which is probably important in protecting the cell from Ca2+ overfilling (PMID: 37007714). TMEM66 is a highly conserved protein in vertebrates. In mammals, TMEM66 is ubiquitously expressed, but has significantly high transcript levels in the immune and neuronal tissues (PMID: 25469256). Moreover, TMEM66 is an androgen-responsive marker for prostate cancer and mTOR-dependent cardiac growth (PMID:32173353).

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