Anticorps Recombinant de lapin anti-TMIGD2/CD28H

TMIGD2/CD28H Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241807A5

N° de cat : 98263-1-PBS

Synonymes

TMIGD2/CD28, Immunoglobulin and proline-rich receptor 1, IGPR-1, IGPR1, CD28H

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98263-1-RR (same clone as 98263-1-PBS)

  1x10^6 HEK-293T cells or TMIGD2/CD28H transfected HEK-293T cells were stained with 0.25 ug Anti-Human TMIGD2/CD28H Rabbit Recombinant Antibody (98263-1-RR, Clone:241807A5) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98263-1-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected HEK-293T using 98263-1-RR (same clone as 98263-1-PBS)

  1x10^6 HEK-293T cells or TMIGD2/CD28H transfected HEK-293T cells were stained with 0.25 ug Anti-Human TMIGD2/CD28H Rabbit Recombinant Antibody (98263-1-RR, Clone: 241807A5) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98263-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98263-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98263-1-RR against Human TMIGD2/CD28H were performed. The affinity constant is 171 nM.

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Informations sur le produit

98263-1-PBS cible TMIGD2/CD28H dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: transmembrane and immunoglobulin domain containing 2
• Masse moléculaire calculée: 282 aa, 31 kDa
• Numéro d’acquisition GenBank: BC015655
• Symbole du gène: TMIGD2
• Identification du gène (NCBI): 126259
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2, also known as CD28H and IGPR1), plays a role in cell-cell interaction, migration, and angiogenesis. Through interaction with HHLA2, it costimulates T-cells in the context of TCR-mediated activation and enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade (PMID: 22419821; 23784006). TMIGD2 has been associated with several diseases, particularly in the context of cancer. It is aberrantly expressed by human AML cells and can be used to identify and enrich functional LSCs (PMID: 38167704).

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