Anticorps Recombinant de lapin anti-TMPRSS2

TMPRSS2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

7I5

N° de cat : 80152-1-PBS

Synonymes

FLJ41954, PP9284, PRSS10, Serine protease 10, TMPRSS2

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Galerie de données de validation

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  WB analysis using 80152-1-RR (same clone as 80152-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 80152-1-RR (TMPRSS2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80152-1-PBS in a different storage buffer formulation.

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Informations sur le produit

80152-1-PBS cible TMPRSS2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TMPRSS2 Protéine recombinante Ag5824
• Nom complet: transmembrane protease, serine 2
• Masse moléculaire calculée: 54 kDa
• Poids moléculaire observé: 55 kDa
• Numéro d’acquisition GenBank: BC051839
• Symbole du gène: TMPRSS2
• Identification du gène (NCBI): 7113
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TMPRSS2, also named as PRSS10, is a type II transmembrane serine protease which is highly expressed by the epithelium of the human prostate gland. TMPRSS2 may contribute to prostate tumor metastasis via the activation of PAR-2. TMPRSS2 is a Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. TMPRSS2 as a host cell factor that is critical for spread of several clinically relevant viruses, including influenza A viruses and coronaviruses (PMID: 23468491, 30626688). SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. The initial spike protein priming by TMPRSS2 is essential for entry and viral spread of SARS-CoV-2 through interaction with the ACE2 receptor (PMID: 32142651, 30626688 ). Camostat mesylate, an inhibitor of TMPRSS2, can block SARS-CoV-2 infection of lung cells (PMID: 32142651). The MW of TMPRSS2 is about 65-70 kDa. It can be cleaved into some chains with MW 54 kDa, 31 kDa and 26 kDa (PMID: 25734995, 20382709, 26018085).

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