Anticorps Polyclonal de lapin anti-TMPRSS6

TMPRSS6 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications(2)

N° de cat : 12950-1-AP

Synonymes

IRIDA, Matriptase 2, TMPRSS6

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Galerie de données de validation

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  WB analysis of HEK-293 using 12950-1-AP

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 12950-1-AP (TMPRSS6 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of MCF-7 using 12950-1-AP

  MCF7 cells were subjected to SDS PAGE followed by western blot with 12950-1-AP (TMPRSS6 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of HepG2 using 12950-1-AP

  HepG2 cells were subjected to SDS PAGE followed by western blot with 12950-1-AP (TMPRSS6 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse liver using 12950-1-AP

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 12950-1-AP (TMPRSS6 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules HEK-293, cellules HepG2, cellules MCF-7, tissu hépatique de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• KD/KO: See 1 publications below
• WB: See 2 publications below
• IF: See 1 publications below

Informations sur le produit

12950-1-AP cible TMPRSS6 dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TMPRSS6 Protéine recombinante Ag4076
• Nom complet: transmembrane protease, serine 6
• Masse moléculaire calculée: 89 kDa
• Poids moléculaire observé: 52 kDa
• Numéro d’acquisition GenBank: BC039082
• Symbole du gène: TMPRSS6
• Identification du gène (NCBI): 164656
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate hemojuvelin (HJV) at the plasma membrane(PMID:21724843).It Belongs to the peptidase S1 family.Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA).It has 4 isoforms produced by alternative splicing.

Publications

Species	Application	Title
mouse	WB	Haematologica; New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia.; Authors - Jing Liu
human,mouse	WB,IF	Cell Death Dis; Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth; Authors - Yong Zuo ; KD Validated

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