Anticorps Monoclonal anti-TNF Alpha
TNF Alpha Monoclonal Antibody for
Hôte / Isotype
Mouse / IgG1
Réactivité testée
Humain
Applications
Conjugaison
CoraLite®555 Fluorescent Dye
CloneNo.
11H8A5
N° de cat : CL555-69002
Synonymes
Galerie de données de validation
Informations sur le produit
CL555-69002 cible TNF Alpha dans les applications de et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Hôte / Isotype | Mouse / IgG1 |
| Clonalité | Monoclonal |
| Type | Anticorps |
| Immunogène | TNF Alpha Protéine recombinante HZ-1014 |
| Nom complet | tumor necrosis factor (TNF superfamily, member 2) |
| Symbole du gène | TNF-alpha |
| Identification du gène (NCBI) | 7124 |
| Conjugaison | CoraLite®555 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 557 nm / 570 nm |
| Forme | Liquide |
| Méthode de purification | Purification par protéine G |
| Tampon de stockage | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Conditions de stockage | Stocker à -20 °C. Éviter toute exposition à la lumière. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA. |
Informations générales
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, INS resistance, and cancer.
This antibody can be used to neutralize the bioactivity of TNF alpha.
