Anticorps Monoclonal anti-TNFAIP8

TNFAIP8 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

3D2F7

N° de cat : 67737-1-PBS

Synonymes

GG2 1, MDC 3.13, NDED, SCC S2, SCCS2, TNF alpha induced protein 8, TNF induced protein GG2 1, TNFAIP8

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Galerie de données de validation

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  WB analysis using 67737-1-Ig (same clone as 67737-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67737-1-Ig (TNFAIP8 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67737-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67737-1-PBS cible TNFAIP8 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: TNFAIP8 Protéine recombinante Ag8805
• Nom complet: tumor necrosis factor, alpha-induced protein 8
• Masse moléculaire calculée: 198 aa, 23 kDa
• Poids moléculaire observé: 19-21 kDa
• Numéro d’acquisition GenBank: BC007014
• Symbole du gène: TNFAIP8
• Identification du gène (NCBI): 25816
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TNFAIP8 (tumor necrosis factor, alpha-induced protein 8), also called SCC-S2/GG2-1/NDED, is associated with enhanced cell survival and inhibition of apoptosis. The induction of TNFAIP8 by TNF depends on the activation of NFκB. TNFAIP8 suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. TNFAIP8 is expressed in adult spleen, lymph node, thymus, thyroid, bone marrow, and placenta, and in fetal liver, lung, and kidney at high levels, also expressed in various tumor tissues and all cancer cell lines tested.

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