Anticorps Recombinant de lapin anti-Osteoprotegerin/TNFRSF11B

Osteoprotegerin/TNFRSF11B Recombinant Antibody for WB, IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

CloneNo.

240168E9

N° de cat : 83506-1-PBS

Synonymes

TNFRSF11B, Osteoprotegerin, Osteoclastogenesis inhibitory factor, OPG, OCIF

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Galerie de données de validation

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  WB analysis of human milk using 83506-1-RR (same clone as 83506-1-PBS)

  human milk was subjected to SDS PAGE followed by western blot with 83506-1-RR (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83506-1-PBS in a different storage buffer formulation.

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  IHC staining of rat kidney using 83506-1-RR (same clone as 83506-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 83506-1-RR (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83506-1-PBS in a different storage buffer formulation.

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  IHC staining of rat kidney using 83506-1-RR (same clone as 83506-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 83506-1-RR (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83506-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 83506-1-RR

  Biolayer interferometry (BLl) kinetic assays of 83506-1 against Human Osteoprotegerin/ TNFRSF11B were performed. The affinity constant is below 1 pM.

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Informations sur le produit

83506-1-PBS cible Osteoprotegerin/TNFRSF11B dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Osteoprotegerin/TNFRSF11B Protéine recombinante Ag2139
• Nom complet: tumor necrosis factor receptor superfamily, member 11b
• Masse moléculaire calculée: 401 aa, 46 kDa
• Poids moléculaire observé: 56 kDa
• Numéro d’acquisition GenBank: BC030155
• Symbole du gène: TNFRSF11B
• Identification du gène (NCBI): 4982
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Osteoprotegerin (OPG), also known as tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) and osteoclastogenesis inhibitory factor (OCIF), belongs to the tumor necrosis factor (TNF) receptor superfamily. By binding to RANKL, OPG inhibits osteoclastic activity and promotes bone formation. OPG plays a key role in cell survival by inhibiting TRAIL-induced apoptosis. OPG also is involved in vascular biology, fibrosis, immunity, EMT, and the apoptosis of cancer cells (PMID: 35523775).

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