Anticorps Recombinant de lapin anti-CD268/BAFF-R

CD268/BAFF-R Recombinant Antibody for Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242003C3

N° de cat : 84585-1-PBS

Synonymes

TNFRSF13C, BAFF R, BAFF receptor, BAFFR, BAFF-R

---

Galerie de données de validation

• 

  Affinity and Kinetic Characterization of 84585-1-PBS

  Biolayer interferometry (BLl) kinetic assay of 84585-1-PBS against Human TNFRSF13C was performed. The affinity constant is 14.9 nM.

---

Informations sur le produit

84585-1-PBS cible CD268/BAFF-R dans les applications de Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CD268/BAFF-R Protéine recombinante Eg1922
• Nom complet: tumor necrosis factor receptor superfamily, member 13C
• Masse moléculaire calculée: 184 aa, 19 kDa
• Numéro d’acquisition GenBank: BC105123
• Symbole du gène: TNFRSF13C
• Identification du gène (NCBI): 115650
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells (PMID: 32528875). The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation (PMID: 30349534). Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells (PMID: 38791453).

{{ptg:RelatedPrimaryAntibodies}}