Anticorps Polyclonal de lapin anti-BCMA/TNFRSF17

BCMA/TNFRSF17 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27724-1-PBS

Synonymes

TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein

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Galerie de données de validation

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  WB analysis of Daudi using 27724-1-AP (same clone as 27724-1-PBS)

  Daudi and Ramos cells were subjected to SDS PAGE followed by western blot with 27724-1-AP (TNFRSF17 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

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  WB analysis of Raji using 27724-1-AP (same clone as 27724-1-PBS)

  Raji cells were subjected to SDS PAGE followed by western blot with 27724-1-AP (TNFRSF17 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

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  WB analysis of Ramos using 27724-1-AP (same clone as 27724-1-PBS)

  Ramos cells were subjected to SDS PAGE followed by western blot with 27724-1-AP (TNFRSF17 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 27724-1-AP (same clone as 27724-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 27724-1-AP (same clone as 27724-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human tonsillitis using 27724-1-AP (same clone as 27724-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human tonsillitis using 27724-1-AP (same clone as 27724-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27724-1-PBS cible BCMA/TNFRSF17 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: BCMA/TNFRSF17 Protéine recombinante Ag27049
• Nom complet: tumor necrosis factor receptor superfamily, member 17
• Masse moléculaire calculée: 184 aa, 20 kDa
• Poids moléculaire observé: 20 kDa
• Numéro d’acquisition GenBank: BC058291
• Symbole du gène: TNFRSF17
• Identification du gène (NCBI): 608
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

BCMA (B cell maturation antigen), also known as TNFRSF17, is 20.2-kDa type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response (PMID: 32943087; 9846698). BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation (PMID: 27127303); when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK (PMID: 36140254). It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM (PMID: 32055000; 32943087).

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