Anticorps Recombinant de lapin anti-TNFRSF21/DR6

TNFRSF21/DR6 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250249D8

N° de cat : 98523-2-PBS

Synonymes

DR6, TNFRSF21, CD358, Death receptor 6, UNQ437/PRO868

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Galerie de données de validation

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  FC experiment of A431 using 98523-2-RR (same clone as 98523-2-PBS)

  1x10^6 A431 cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98523-2-PBS in a different storage buffer formulation.

• 

  FC experiment of A431 using 98523-2-RR (same clone as 98523-2-PBS)

  1x10^6 A431 cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98523-2-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected CHO using 98523-2-RR (same clone as 98523-2-PBS)

  1x10^6 HEK-293T cells or TNFRSF21/DR6-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98523-2-PBS in a different storage buffer formulation.

• 

  FC experiment of Transfected CHO using 98523-2-RR (same clone as 98523-2-PBS)

  1x10^6 HEK-293T cells or TNFRSF21/DR6-transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human TNFRSF21/DR6 Rabbit RecAb (98523-2-RR, Clone: 250249D8) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98523-2-PBS in a different storage buffer formulation.

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Informations sur le produit

98523-2-PBS cible TNFRSF21/DR6 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TNFRSF21/DR6 Protéine recombinante Eg2718
• Nom complet: tumor necrosis factor receptor superfamily, member 21
• Masse moléculaire calculée: 72 kDa
• Numéro d’acquisition GenBank: NM_014452.5
• Symbole du gène: DR6
• Identification du gène (NCBI): 27242
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

TNFRSF21 (also known as DR6 or CD358) is an orphan receptor of the tumor necrosis factor (TNF) receptor superfamily. It controls cell death and differentiation in a cell-autonomous manner in different cell types including neurons, oligodendrocytes, endothelial cells, and immune cells (PMID: 29459438). DR6 has been shown to activate NF-κB and JNK, and induce cell apoptosis (PMID: 9714541). DR6 interacts with TRADD, which is known to mediate signal transduction of TNF receptors. It has been reported that APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, indicating that DR6 might be involved in Alzheimer's disease (PMID: 19225519).

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