Anticorps Recombinant de lapin anti-TNFRSF9/CD137

TNFRSF9/CD137 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241647E11

N° de cat : 98182-1-PBS

Synonymes

241647E11, 4-1BB, 4-1BB ligand receptor, CD137, Ila

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98182-1-RR (same clone as 98182-1-PBS)

  1x10^6 untreated or Con A treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse TNFRSF9/CD137 Rabbit Recombinant Antibody (98182-1-RR, Clone: 241647E11) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Mouse CD25 (PC61.5) (APC-65137, Clone: PC61.5). Cells were not fixed. This data was developed using the same antibody clone with 98182-1-PBS in a different storage buffer formulation.

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  FC experiment of mouse splenocytes using 98182-1-RR (same clone as 98182-1-PBS)

  1x10^6 Con A treated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse TNFRSF9/CD137 Rabbit Recombinant Antibody (98182-1-RR, Clone: 241647E11) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). 1x10^6 untreated mouse splenocytes were surface stained with 0.25 ug Anti-Mouse TNFRSF9/CD137 Rabbit Recombinant Antibody (98182-1-RR, Clone: 241647E11) and PE-Conjugated Goat Anti-Rabbit IgG(H+L) (black, dashed). Cells were not fixed. This data was developed using the same antibody clone with 98182-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98182-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98182-1-RR against Mouse TNFRSF9/CD137 were performed. The affinity constant is 62.5 pM.

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Informations sur le produit

98182-1-PBS cible TNFRSF9/CD137 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TNFRSF9/CD137 Protéine recombinante Eg1627
• Nom complet: tumor necrosis factor receptor superfamily, member 9
• Masse moléculaire calculée: 28 kDa
• Numéro d’acquisition GenBank: NM_001077509.1
• Symbole du gène: Tnfrsf9
• Identification du gène (NCBI): 21942
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD137, also known as TNFRSF9 or 4-1BB, is an inducible T cell surface receptor that belongs to the tumor necrosis factor receptor superfamily. CD137 is a transmembrane protein expressed on the surface of activated T-cells. In addition, activation-dependent expression of CD137 has also been found in B lymphocytes, monocytes, and diverse nonlymphoid cell types. CD137 provides a co-stimulatory signal that enhances the survival, and differentiation of cells, and has a crucial role in the development of CD8 cytotoxic T cells and anti-tumor immunity. (PMID: 9826581; 23696891)

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