Anticorps Recombinant de lapin anti-TNFSF15

TNFSF15 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251018A11

N° de cat : 83700-3-PBS

Synonymes

TNFSF 15, Tumor necrosis factor ligand superfamily member 15, Tumor necrosis factor ligand superfamily member 15, membrane form, Tumor necrosis factor ligand superfamily member 15, secreted form

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Galerie de données de validation

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  WB analysis using 83700-3-RR (same clone as 83700-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 83700-3-RR (TNFSF15 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83700-3-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 83700-3-RR

  Biolayer interferometry (BLl) kinetic assays of 83700-3-RR against Human TNFSF15 were performed. The affinity constant is 0.291 nM.

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Informations sur le produit

83700-3-PBS cible TNFSF15 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TNFSF15 Protéine recombinante Eg32092
• Nom complet: tumor necrosis factor (ligand) superfamily, member 15
• Masse moléculaire calculée: 28 kDa
• Poids moléculaire observé: 28 kDa
• Numéro d’acquisition GenBank: BC074941
• Symbole du gène: TNFSF15
• Identification du gène (NCBI): 9966
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Tumor necrosis factor ligand superfamily member 15 (TNFSF15) is also named as TL1 and VEGI. And it belongs to the tumor necrosis factor family. It is a receptor for TNFRSF25 and TNFRSF6B. VEGI induced degradation of IκB alpha, and nuclear translocation of p65 subunit of NFκB by activating NFκB (PMID: 10597252). TL1A mediates activation and apoptosis of NFκB in DR3-expressing cell lines (PMID: 11911831). Overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression. The isoforms show endothelial cell-specific expression and are generated from a 17 kb human gene by alternative splicing (PMID: 11923219). In addition, VEGI can inhibit vascular endothelial growth and angiogenesis (in vitro) (PMID: 9872942).

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