Anticorps Recombinant de lapin anti-TOLLIP

TOLLIP Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242098C6

N° de cat : 84711-6-PBS

Synonymes

Toll-interacting protein, toll interacting protein, IL 1RAcPIP, 242098C6

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Galerie de données de validation

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  WB analysis using 84711-6-RR (same clone as 84711-6-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84711-6-RR (TOLLIP antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84711-6-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84711-6-RR

  Biolayer interferometry (BLl) kinetic assays of 84711-6-RR against Human TOLLIP were performed. The affinity constant is 1.32 nM.

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Informations sur le produit

84711-6-PBS cible TOLLIP dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TOLLIP Protéine recombinante Ag1864
• Nom complet: toll interacting protein
• Masse moléculaire calculée: 30 kDa
• Poids moléculaire observé: 30 kDa
• Numéro d’acquisition GenBank: BC012057
• Symbole du gène: TOLLIP
• Identification du gène (NCBI): 54472
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TOLLIP (Toll interacting protein), is an inhibitory adaptor protein. Tollip is a negative regulator of IL-1R and Toll-like receptors signalling pathway, involved in inflammatory immune response and inhibiting IRAK1 phosphorylation and kinase activity (PMID:11441107, PMID:10854325, PMID:11751856). The TOLLIP-dependent selective autophagy pathway plays a role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).

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