Anticorps Polyclonal de lapin anti-TPSB2

TPSB2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15332-1-PBS

Synonymes

EC:3.4.21.59, TPS2, Tryptase 2, tryptase beta 2, Tryptase beta-2

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Galerie de données de validation

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  WB analysis using 15332-1-AP (same clone as 15332-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 15332-1-AP (TPSB2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. TPSB2 deficient cell line K-562 served as a negative control. This data was developed using the same antibody clone with 15332-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15332-1-PBS cible TPSB2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TPSB2 Protéine recombinante Ag7335
• Nom complet: tryptase beta 2
• Masse moléculaire calculée: 31 kDa
• Poids moléculaire observé: 31 kDa
• Numéro d’acquisition GenBank: BC065923
• Symbole du gène: TPSB2
• Identification du gène (NCBI): 64499
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Tryptase beta-2 (TPSB2), also known as TPS2, is a member of the peptidase S1 family and the mast cell-specific tryptase subfamily. It is a serine protease primarily expressed in mast cells and basophils. TPSB2 is synthesized as a proenzyme, stored in secretory granules, and released upon cell activation. It plays a crucial role in allergic reactions and inflammation by cleaving extracellular matrix proteins, activating protease-activated receptors (PARs), and processing cytokines like IL-33. Elevated levels of TPSB2 are associated with conditions such as asthma, allergic rhinitis, and anaphylaxis, making it a biomarker and therapeutic target in these areas.

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