Anticorps Recombinant de lapin anti-TRIM26

TRIM26 Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242154B5

N° de cat : 84661-4-PBS

Synonymes

242154B5, EC:2.3.2.27, RNF95, TRIM, Tripartite motif-containing protein 26

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Galerie de données de validation

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  WB analysis using 84661-4-RR (same clone as 84661-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84661-4-RR (TRIM26 antibody) at dilution of 1:12000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84661-4-PBS in a different storage buffer formulation.

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  IHC staining of human rectal cancer using 84661-4-RR (same clone as 84661-4-PBS)

  Immunohistochemical analysis of paraffin-embedded human rectal cancer tissue slide using 84661-4-RR (TRIM26 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84661-4-PBS in a different storage buffer formulation.

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  IHC staining of human rectal cancer using 84661-4-RR (same clone as 84661-4-PBS)

  Immunohistochemical analysis of paraffin-embedded human rectal cancer tissue slide using 84661-4-RR (TRIM26 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84661-4-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84661-4-RR

  Biolayer interferometry (BLl) kinetic assays of 84661-4-RR against Human TRIM26 were performed. The affinity constant is 47.3 pM.

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Informations sur le produit

84661-4-PBS cible TRIM26 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TRIM26 Protéine recombinante Ag25546
• Nom complet: tripartite motif-containing 26
• Masse moléculaire calculée: 62 kDa
• Poids moléculaire observé: 60-70 kDa
• Numéro d’acquisition GenBank: BC024039
• Symbole du gène: TRIM26
• Identification du gène (NCBI): 7726
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TRIM26 is a member of the tripartite motif (TRIM) protein family composed of more than 70 members in human. TRIM proteins share a similar characteristic structure, which includes a RING (R) domain, one or two B-boxes (B), and a coiled coil (CC) domain in the N-terminal and a domain in the C-terminal with variable structures. TRIM26 potentiates virus-triggered IRF3, NF-κB activation, IFN-β induction, and cellular antiviral responses. Further investigation suggests that TRIM26 plays an important role in the antiviral innate immune response by bridging TBK1 to NEMO and mediating TBK1 activation. (PMID: 25763818, PMID: 26611359)

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