Anticorps Polyclonal de lapin anti-TRIM52

TRIM52 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20948-1-PBS

Synonymes

RNF102, tripartite motif containing 52

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Galerie de données de validation

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  WB analysis using 20948-1-AP (same clone as 20948-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 20948-1-AP (TRIM52 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20948-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary cancer using 20948-1-AP (same clone as 20948-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 20948-1-AP (TRIM52 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20948-1-PBS in a different storage buffer formulation.

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Informations sur le produit

20948-1-PBS cible TRIM52 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TRIM52 Protéine recombinante Ag15064
• Nom complet: tripartite motif-containing 52
• Masse moléculaire calculée: 297 aa, 35 kDa
• Poids moléculaire observé: 35 kDa
• Numéro d’acquisition GenBank: BC007372
• Symbole du gène: TRIM52
• Identification du gène (NCBI): 84851
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TRIM52 (Tripartite motif 52) is a member of the family of highly conserved RBCC (a RING-finger, two B-boxes, and a predicted alpha-helical Coiled-Coil domain were linked to the N-terminal region in sequence) proteins with more than 70 isoforms, which plays an important role in tumorigenesis through different signaling pathways (PMID: 35837156). TRIM52 promotes tumorigenesis in ovarian cancer by activating the nuclear factor (NF)-κB signaling pathway. Knocking-down of TRIM52 in ovarian cancer cells suppresses cell invasion, cell migration and cell proliferation, while inducing apoptosis (PMID: 30918473, 28073078).

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