Anticorps Polyclonal de lapin anti-TRMT10B

TRMT10B Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33056-1-PBS

Synonymes

EC:2.1.1.221, RG9MTD3, RNA (guanine-9-)-methyltransferase domain-containing protein 3, tRNA (guanine(9)-N(1))-methyltransferase TRMT10B, tRNA methyltransferase 10 homolog B

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Galerie de données de validation

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  WB analysis using 33056-1-AP (same clone as 33056-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33056-1-AP (RG9MTD3 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33056-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33056-1-PBS cible TRMT10B dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TRMT10B Protéine recombinante Ag36835
• Nom complet: RNA (guanine-9-) methyltransferase domain containing 3
• Masse moléculaire calculée: 36 kDa
• Poids moléculaire observé: 40 kDa
• Numéro d’acquisition GenBank: BC012175
• Symbole du gène: RG9MTD3
• Identification du gène (NCBI): 158234
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The TRM10 family of methyltransferases is responsible for the N1-methylation of purines at position 9 of tRNAs in Archaea and Eukarya. The human genome encodes three TRM10-type enzymes. TRMT10B is the first m1A9-specific tRNA methyltransferase found in eukaryotes and is responsible for the modification of a single nuclear-encoded tRNA. Furthermore, we show that the lack of G9 methylation causes a decrease in the steady-state levels of the initiator tRNAiMet-CAT and an alteration in its further post-transcriptional modification (PMID: 32392304).

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