Anticorps Polyclonal de lapin anti-TRPA1

TRPA1 Polyclonal Antibody for WB, IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, porc, rat, souris

Applications

WB, IHC, IF, ELISA

Conjugaison

Non conjugué

Publications(31)

N° de cat : 19124-1-AP

Synonymes

ANKTM1, p120, Wasabi receptor



Applications testées

Résultats positifs en WBcellules SH-SY5Y, tissu de côlon de porc
Résultats positifs en IHCtissu de cervelet de souris, tissu cérébral de souris
il est suggéré de démasquer l'antigène avec un tampon de TE buffer pH 9.0; (*) À défaut, 'le démasquage de l'antigène peut être 'effectué avec un tampon citrate pH 6,0.

Dilution recommandée

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
Immunohistochimie (IHC)IHC : 1:250-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

19124-1-AP cible TRPA1 dans les applications de WB, IHC, IF, ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

Réactivité Humain, porc, rat, souris
Réactivité citéerat, Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet transient receptor potential cation channel, subfamily A, member 1
Masse moléculaire calculée 140 kDa
Poids moléculaire observé 120-130 kDa
Numéro d’acquisition GenBankNM_007332
Symbole du gène TRPA1
Identification du gène (NCBI) 8989
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS with 0.02% sodium azide and 50% glycerol
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

TRPA1, also named as ANKTM1, belongs to the transient receptor family. TRPA1 is a receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. It acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. It may be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds.

Protocole

Product Specific Protocols
WB protocol for TRPA1 antibody 19124-1-APDownload protocol
IHC protocol for TRPA1 antibody 19124-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB,IF

Metabolism

IFT80 and TRPA1 cooperatively regulate bone formation by calcium signaling in response to mechanical stimuli

Authors - Ting Wang
ratWB

Phytomedicine

Yu-Xue-Bi capsule ameliorates aggressive synovitis and joint damage in rheumatoid arthritis via modulating the SUCNR1/HIF-1α/TRPV1 axis

Authors - Wenjia Chen
mouseIHC

J Control Release

A dual receptors-targeting and size-switchable "cluster bomb" co-loading chemotherapeutic and transient receptor potential ankyrin 1 (TRPA-1) inhibitor for treatment of triple negative breast cancer.

Authors - Yashi Wang

Front Pharmacol

The efficacy of ophiopogonanone B in treating the cough in mice infected with Mycoplasma pneumoniae

Authors - Nan-Nan Liu
rat,humanWB,IF

J Ethnopharmacol

Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury

Authors - Kaixue Zhang
mouseWB,IF

Mol Nutr Food Res

Menthol from Mentha piperita Suppresses the Milk Production of Lactating Mammary Epithelial Cells In Vivo and In Vitro.

Authors - Norihiro Suzuki
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