Anticorps Polyclonal de lapin anti-TRPV4

TRPV4 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27892-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 27892-1-AP (same clone as 27892-1-PBS)

  SH-SY5Y cell lysates (heated at 100℃, heated at 37℃) were subjected to SDS PAGE followed by western blot with 27892-1-AP (TRPV4 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27892-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27892-1-PBS cible TRPV4 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TRPV4 Protéine recombinante Ag27253
• Nom complet: transient receptor potential cation channel, subfamily V, member 4
• Masse moléculaire calculée: 98 kDa
• Poids moléculaire observé: 85~98 kDa
• Numéro d’acquisition GenBank: NM_001177428.1
• Symbole du gène: TRPV4
• Identification du gène (NCBI): 59341
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TRPV4, also named as VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3), spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MTD). Multiple transcript variants encoding different isoforms have been found.

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