Anticorps Recombinant de lapin anti-TSLP

TSLP Recombinant Antibody for FC (Intra)

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC (Intra)

Conjugaison

Non conjugué

CloneNo.

241821B2

N° de cat : 98247-1-PBS

Synonymes

Thymic stromal lymphopoietin, 241821B2

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Galerie de données de validation

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  FC experiment of HUVEC using 98247-1-RR (same clone as 98247-1-PBS)

  1x10^6 untreated or IL-4, TNF-α and BFA-treated HUVEC cells were intracellularly stained with 0.25 ug Anti-Human TSLP Rabbit RecAb (98247-1-RR, Clone: 241821B2) and APC-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98247-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98247-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98247-1-RR against Human TSLP were performed. The affinity constant is 2.85 nM.

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Informations sur le produit

98247-1-PBS cible TSLP dans les applications de FC (Intra) et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: thymic stromal lymphopoietin
• Masse moléculaire calculée: 18 kDa
• Numéro d’acquisition GenBank: NM_033035.5
• Symbole du gène: TSLP
• Identification du gène (NCBI): 85480
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain, it mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Another isoform of this protein may act as an antimicrobial peptide in the oral cavity and on the skin (PMID: 24850429).

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