Anticorps Polyclonal de lapin anti-TSPO/PBR

TSPO/PBR Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15444-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of HEK-293 using 15444-1-AP (same clone as 15444-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 15444-1-AP (TSPO/PBR antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15444-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 15444-1-AP (same clone as 15444-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 15444-1-AP (TSPO/PBR antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15444-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 15444-1-AP (same clone as 15444-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 15444-1-AP (TSPO antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15444-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15444-1-PBS cible TSPO/PBR dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TSPO/PBR Protéine recombinante Ag7475
• Nom complet: translocator protein (18kDa)
• Masse moléculaire calculée: 18 kDa
• Poids moléculaire observé: 18 kDa
• Numéro d’acquisition GenBank: BC001110
• Symbole du gène: TSPO
• Identification du gène (NCBI): 706
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TSPO, also named Peripheral-type benzodiazepine receptor (PBR), encodes the translocator protein, belonging to tryptophan-rich sensory protein family. The protein is mainly localized in the outer mitochondrial membrane and expressed in steroid-synthesizing tissues (PMID:32881658, PMID:1326278). TSPO is involved in the translocation of cholesterol from the outer to inner mitochondrial membrane (PMID:21119734). In response to injury, TSPO has a upregulated expression in the peripheral nervous system (PMID:32423330, PMID:23251719). TSPO is also as a biomarker in a non-invasive procedure including detecting the inflammation in the heart and atherosclerotic plaques (PMID:24402571).

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