Anticorps Polyclonal de lapin anti-TTBK1

TTBK1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32938-1-PBS

Synonymes

BDTK, Brain-derived tau kinase, EC:2.7.11.1, KIAA1855, Tau-tubulin kinase 1

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Galerie de données de validation

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  WB analysis using 32938-1-AP (same clone as 32938-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32938-1-AP (TTBK1 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32938-1-PBS in a different storage buffer formulation.

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Informations sur le produit

32938-1-PBS cible TTBK1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TTBK1 Protéine recombinante Ag36655
• Nom complet: tau tubulin kinase 1
• Masse moléculaire calculée: 142/70 kDa
• Poids moléculaire observé: 200 kDa
• Numéro d’acquisition GenBank: BC036764
• Symbole du gène: TTBK1
• Identification du gène (NCBI): 84630
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TTBK1 (Tau Tubulin kinase 1), also known as BDTK (brain-derived Tau kinase), is a 1,321 amino acid protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, TTBK1 functions as a serine/threonine kinase that can phosphorylate Tau (a protein involved in Tubulin polymerization) on threonine, tyrosine and serine residues. Specifically, TTBK1 uses divalent cations, such as magnesium and manganese, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, creating a phosphoprotein and ADP. Phosphorylation of Tau causes its aggregation and subsequent loss of function, suggesting an important role for TTBK1 in the control of Tubulin dynamics. Two isoforms of TTBK1 are expressed due to alternative splicing events. The molecular weight observed is consistent with what has been described in PMID:16923168.

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