Anticorps Polyclonal de lapin anti-TTBK2

• Phare
• Validé par KD/KO

TTBK2 Polyclonal Antibody for WB, IHC, IF/ICC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, IF/ICC, ELISA

Conjugaison

Non conjugué

N° de cat : 15072-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of PC-3 using 15072-1-AP (same clone as 15072-1-PBS)

  PC-3 cells were subjected to SDS PAGE followed by western blot with 15072-1-AP (TTBK2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15072-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 15072-1-AP (same clone as 15072-1-PBS)

  WB result of TTBK2 antibody (15072-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TTBK2 transfected HeLa cells. This data was developed using the same antibody clone with 15072-1-PBS in a different storage buffer formulation.

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  WB analysis of SH-SY5Y using 15072-1-AP (same clone as 15072-1-PBS)

  SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 15072-1-AP (TTBK2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15072-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 15072-1-AP (same clone as 15072-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 15072-1-AP (TTBK2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15072-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 15072-1-AP (same clone as 15072-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 15072-1-AP (TTBK2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15072-1-PBS in a different storage buffer formulation.

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  IHC staining of human prostate cancer using 15072-1-AP

  Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 15072-1-AP (TTBK2 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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  IHC staining of human prostate cancer using 15072-1-AP

  Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 15072-1-AP (TTBK2 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

• 

  IHC staining of human prostate cancer using 15072-1-AP (same clone as 15072-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 15072-1-AP (TTBK2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15072-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human prostate cancer using 15072-1-AP (same clone as 15072-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 15072-1-AP (TTBK2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15072-1-PBS in a different storage buffer formulation.

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  IF Staining of hTERT-RPE1 using 15072-1-AP (same clone as 15072-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed hTERT-RPE1 cells using TTBK2 antibody (15072-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CoraLite®594 ARL13B antibody (CL594-17711, red). This data was developed using the same antibody clone with 15072-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15072-1-PBS cible TTBK2 dans les applications de WB, IHC, IF/ICC, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TTBK2 Protéine recombinante Ag7108
• Nom complet: tau tubulin kinase 2
• Masse moléculaire calculée: 137 kDa
• Poids moléculaire observé: 137-150 kDa
• Numéro d’acquisition GenBank: BC071556
• Symbole du gène: TTBK2
• Identification du gène (NCBI): 146057
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TTBK2(tau tubulin kinase 2) plays an important role in the tau cascade and in spinocerebellar degeneration. The N-terminus of TTBK2 has a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK1 and TTBK2 function as regulators of TDP-43 phosphorylation. TTBK1/2 may be attractive drug targets for therapeutic interventions in TDP-43 proteinopathies such as FTLD-TDP and ALS.(PMID:25473830). 15072-1-AP has a cross reaction with TTBK1.

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