Anticorps Recombinant de lapin anti-TTBK2

• Phare
• Validé par KD/KO

TTBK2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241456B4

N° de cat : 84634-1-PBS

Synonymes

241456B4, EC:2.7.11.1, KIAA0847, SCA11, tau tubulin kinase 2

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Galerie de données de validation

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  WB analysis using 84634-1-RR (same clone as 84634-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84634-1-RR (TTBK2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 84634-1-RR (same clone as 84634-1-PBS)

  WB result of TTBK2 antibody (84634-1-RR; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TTBK2 transfected HeLa cells. This data was developed using the same antibody clone with 84634-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84634-1-RR

  Biolayer interferometry (BLl) kinetic assays of 84634-1-RR against Human TTBK2 were performed. The affinity constant is 0.14 nM.

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Informations sur le produit

84634-1-PBS cible TTBK2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TTBK2 Protéine recombinante Ag7108
• Nom complet: tau tubulin kinase 2
• Masse moléculaire calculée: 137 kDa
• Poids moléculaire observé: 137-150 kDa
• Numéro d’acquisition GenBank: BC071556
• Symbole du gène: TTBK2
• Identification du gène (NCBI): 146057
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TTBK2(tau tubulin kinase 2) plays an important role in the tau cascade and in spinocerebellar degeneration. The N-terminus of TTBK2 has a serine-threonine-tyrosine kinase domain, and a C-terminal region shows homology to TTBK1. TTBK1 and TTBK2 function as regulators of TDP-43 phosphorylation. TTBK1/2 may be attractive drug targets for therapeutic interventions in TDP-43 proteinopathies such as FTLD-TDP and ALS.(PMID:25473830).

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