Anticorps Recombinant de lapin anti-TTK

• Phare
• Validé par KD/KO

TTK Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241873B2

N° de cat : 84744-1-PBS

Synonymes

241873B2, EC:2.7.12.1, ESK, hMPS1, Mps 1

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Galerie de données de validation

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  WB analysis using 84744-1-RR (same clone as 84744-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 84744-1-RR (TTK antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84744-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 84744-1-RR (same clone as 84744-1-PBS)

  WB result of TTK antibody (84744-1-RR; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TTK transfected HEK-293 cells. This data was developed using the same antibody clone with 84744-1-PBS in a different storage buffer formulation.

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Informations sur le produit

84744-1-PBS cible TTK dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TTK Protéine recombinante Ag20556
• Nom complet: TTK protein kinase
• Masse moléculaire calculée: 97 kDa
• Poids moléculaire observé: 97 kDa
• Numéro d’acquisition GenBank: BC000633
• Symbole du gène: TTK
• Identification du gène (NCBI): 7272
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Mps1 family of kinases colocalizes with mitotic checkpoint proteins in kinetochores and/or spindle pole bodies/centrosomes. TTK has been shown to be a cell cycle-regulated kinase displaying maximum activity during M phase(PMID:15618221). Its kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule-chromosome attachment error correction and the mitotic checkpoint(PMID:20937696). TTK mRNA is present at relatively high levels in testis and thymus, tissues which contain a large number of proliferating cells, but is not detected in most other benign tissues (PMID:1639825). It has 2 isoforms produced by alternative splicing (PMID:25137017).

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