Anticorps Recombinant de lapin anti-TWEAKR/CD266

TWEAKR/CD266 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241646F11

N° de cat : 98382-2-PBS

Synonymes

TNFRSF12, TWEAK R, CD266, FGF-inducible 14, Fgfrp2

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98382-2-RR (same clone as 98382-2-PBS)

  1x10^6 HEK-293T cells or TWEAKR/CD266 transfected HEK-293T cells were stained with 0.25 ug Anti-Mouse TWEAK R/TNFRSF12 Rabbit RecAb (98382-2-RR, Clone:241646F11) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98382-2-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98382-2-RR (same clone as 98382-2-PBS)

  1x10^6 HEK-293T cells(left) or TWEAK R/TNFRSF12 transfected HEK-293T cells(right) were stained with 0.25 ug Anti-Mouse TWEAK R/TNFRSF12 Rabbit RecAb (98382-2-RR, Clone:241646F11)(red) , or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98382-2-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98382-2-RR

  Biolayer interferometry (BLl) kinetic assays of 98382-2-RR against Mouse TWEAKR/CD266 were performed. The affinity constant is 0.983 nM.

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Informations sur le produit

98382-2-PBS cible TWEAKR/CD266 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TWEAKR/CD266 Protéine recombinante Eg1838
• Nom complet: tumor necrosis factor receptor superfamily, member 12a
• Masse moléculaire calculée: 14kDa
• Numéro d’acquisition GenBank: NM_013749.2
• Symbole du gène: Tnfrsf12a
• Identification du gène (NCBI): 27279
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

TWEAKR (also known as CD266, FN14, TNFRSF12A) is a member of the TNF receptor superfamily which is activated by its ligand, the cytokine TWEAK (TNFSF12). TWEAKR is the smallest member of the TNFR superfamily. TweakR was first described as an FGF-inducible gene that played a role in fibroblast adhesion and migration. Subsequently, the induction of TweakR expression by other growth factors and/or upon tissue injury was observed in multiple cell types, including hepatocytes, endothelial cells, adipocytes, and cardiomyocytes. (PMID: 23073510, PMID: 24409185)

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