Anticorps Polyclonal de lapin anti-TXLNB

TXLNB Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

N° de cat : 22090-1-AP

Synonymes

MDP77, LST001, hMDP77, C6orf198, Beta-taxilin

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Galerie de données de validation

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  WB analysis using 22090-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 22090-1-AP (TXLNB antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu cardiaque humain, tissu cardiaque de souris

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

22090-1-AP cible TXLNB dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TXLNB Protéine recombinante Ag17295
• Nom complet: taxilin beta
• Masse moléculaire calculée: 684 aa, 77 kDa
• Poids moléculaire observé: 75 kDa
• Numéro d’acquisition GenBank: BC115383
• Symbole du gène: TXLNB
• Identification du gène (NCBI): 167838
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

TXLNB (Taxilin beta, gliding protein beta) is a protein enriched predominantly in cardiomyocytes and belongs to the centrosome articulating protein family. It is localized in the perinuclear region of the centrosome and is closely associated with the microtubule organizing center (MTOC) and the ubiquitin-proteasome system (UPS). TXLNB plays an important role in protein homeostasis in cardiomyocytes, affecting intracellular protein degradation and quality control by regulating the interactions between centrosomes and proteasomes. TXLNB was found to have a key role in cardiomyocyte hypertrophy and cardiac proteotoxicity, and its overexpression enhances proteasome activity and reduces the accumulation of ubiquitylated proteins, whereas knockdown leads to proteasome insufficiency and a decline in cardiac function with age. In addition, TXLNB may be involved in the dynamic regulation of the cytoskeleton and microtubules.

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