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Anticorps Polyclonal de lapin anti-TXLNB

TXLNB Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 22090-1-PBS

Synonymes

MDP77, LST001, hMDP77, C6orf198, Beta-taxilin

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using TXLNB Polyclonal antibody (22090-1-AP)

    WB analysis using 22090-1-AP (same clone as 22090-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22090-1-AP (TXLNB antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22090-1-PBS in a different storage buffer formulation.

Informations sur le produit

22090-1-PBS cible TXLNB dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène TXLNB Protéine recombinante Ag17295
Nom complet taxilin beta
Masse moléculaire calculée 684 aa, 77 kDa
Poids moléculaire observé75 kDa
Numéro d’acquisition GenBankBC115383
Symbole du gène TXLNB
Identification du gène (NCBI) 167838
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TXLNB (Taxilin beta, gliding protein beta) is a protein enriched predominantly in cardiomyocytes and belongs to the centrosome articulating protein family. It is localized in the perinuclear region of the centrosome and is closely associated with the microtubule organizing center (MTOC) and the ubiquitin-proteasome system (UPS). TXLNB plays an important role in protein homeostasis in cardiomyocytes, affecting intracellular protein degradation and quality control by regulating the interactions between centrosomes and proteasomes. TXLNB was found to have a key role in cardiomyocyte hypertrophy and cardiac proteotoxicity, and its overexpression enhances proteasome activity and reduces the accumulation of ubiquitylated proteins, whereas knockdown leads to proteasome insufficiency and a decline in cardiac function with age. In addition, TXLNB may be involved in the dynamic regulation of the cytoskeleton and microtubules.

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