Anticorps Polyclonal de lapin anti-TXNDC15

• Phare
• Validé par KD/KO

TXNDC15 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32874-1-PBS

Synonymes

C5orf14, Thioredoxin Domain Containing 15, Thioredoxin domain-containing protein 15, UNQ335/PRO534

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Galerie de données de validation

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  WB analysis of HeLa using 32874-1-AP (same clone as 32874-1-PBS)

  WB result of TXNDC15 antibody (32874-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-TXNDC15 transfected HeLa cells. This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

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  WB analysis using 32874-1-AP (same clone as 32874-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32874-1-AP (TXNDC15 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary cancer using 32874-1-AP (same clone as 32874-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 32874-1-AP (TXNDC15 antibody) at dilution of 1:600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 32874-1-PBS in a different storage buffer formulation.

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Informations sur le produit

32874-1-PBS cible TXNDC15 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TXNDC15 Protéine recombinante Ag37138
• Nom complet: thioredoxin domain containing 15
• Poids moléculaire observé: 55 kDa
• Numéro d’acquisition GenBank: BC032568
• Symbole du gène: TXNDC15
• Identification du gène (NCBI): 79770
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TXNDC15 (thioredoxin domain-containing protein 15) is a single-pass type I transmembrane protein that contains a thioredoxin domain and is primarily localized in the cytoplasm. It plays a positive regulatory role in the Hedgehog signaling pathway within cilia and actively participates in the process of ciliogenesis, exerting significant influence on the structure and function of cilia-an essential cellular organelle. Additionally, TXNDC15 has been found to form mixed disulfide complexes with endoplasmic reticulum-resident protein disulfide isomerase (PDI) family members, such as ERp57, PDI, and ERp44, suggesting its involvement in protein folding and quality control processes. Notably, mutations in the TXNDC15 gene are associated with a rare and lethal genetic disorder known as Meckel-Gruber syndrome, which is caused by defects in ciliogenesis.

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