Anticorps Polyclonal de lapin anti-TXNIP

• Phare
• Validé par KD/KO

TXNIP Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18243-1-PBS

Synonymes

Thioredoxin binding protein 2, thioredoxin interacting protein, Thioredoxin-binding protein 2, Thioredoxin-interacting protein, VDUP1

---

Galerie de données de validation

• 

  WB analysis of K-562 using 18243-1-AP (same clone as 18243-1-PBS)

  WB result of TXNIP antibody (18243-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-TXNIP transfected K-562 cells. This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 18243-1-AP (same clone as 18243-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18243-1-AP (TXNIP antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary tumor using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human ovary tumor using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse colon using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of rat kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse kidney using 18243-1-AP (same clone as 18243-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

18243-1-PBS cible TXNIP dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TXNIP Protéine recombinante Ag13009
• Nom complet: thioredoxin interacting protein
• Masse moléculaire calculée: 391 aa, 44 kDa
• Poids moléculaire observé: 44-55 kDa
• Numéro d’acquisition GenBank: BC093702
• Symbole du gène: TXNIP
• Identification du gène (NCBI): 10628
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TXNIP, also known as VDUP-1 or TBP-2, belongs to alpha-arrestin protein family and is perhaps the only family member known to bind thioredoxin (TRX). TXNIP was induced by Vitamin D3, but not induced by another monocyte or macrophage differentiation inducer: phorbol 12-myristate 13-acetate (PMA). TXNIP bound catalytic active center of thioredoxin (TRX), which protected cells against oxidative stress. TXNIP was found to be a negative regulator of thioredoxin activity and inducer of the intracellular level of reactive oxygen species (ROS). TXNIP plays an important role in a wide variety of biological functions, such as the regulation of cell death, growth, differentiation, and energy metabolism.

{{ptg:RelatedPrimaryAntibodies}}