Anticorps Recombinant de lapin anti-TYRO3

TYRO3 Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242477G1

N° de cat : 84929-6-PBS

Synonymes

RSE, EC:2.7.10.1, Dtk, BYK, Brt

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Galerie de données de validation

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  WB analysis using 84929-6-RR (same clone as 84929-6-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84929-6-RR (TYRO3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84929-6-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 84929-6-RR (same clone as 84929-6-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 84929-6-RR (TYRO3 antibody) at dilution of 1:250 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84929-6-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 84929-6-RR (same clone as 84929-6-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 84929-6-RR (TYRO3 antibody) at dilution of 1:250 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84929-6-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84929-6-RR

  Biolayer interferometry (BLl) kinetic assays of 84929-6-RR against Human TYRO3 were performed. The affinity constant is 0.133 nM.

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Informations sur le produit

84929-6-PBS cible TYRO3 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TYRO3 Protéine recombinante Ag29527
• Nom complet: TYRO3 protein tyrosine kinase
• Masse moléculaire calculée: 97 kDa
• Poids moléculaire observé: 130 kDa
• Numéro d’acquisition GenBank: BC049368
• Symbole du gène: TYRO3
• Identification du gène (NCBI): 7301
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TYRO3 has a structure includes a cytoplasmic domain and an extracellular ligand binding region. And ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. TYRO3 is associated with many physiological processes including cell survival, migration and differentiation. It has been reported that TYRO3 can be expressed in various regions of the mammalian central nervous system. The molecular mass of TYRO3 is 130 kDa, the apparent molecular mass is higher due to glycosylation.((PMID: 8873131, 23354874, 21539887)

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