Anticorps Recombinant de lapin anti-Tie-2/CD202b

Tie-2/CD202b Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250234F8

N° de cat : 86010-2-PBS

Synonymes

TEK, Angiopoietin 1 receptor, Angiopoietin-1 receptor, CD202B, EC:2.7.10.1

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Galerie de données de validation

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  WB analysis of human placenta using 86010-2-RR (same clone as 86010-2-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 86010-2-RR (TEK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86010-2-PBS in a different storage buffer formulation.

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  WB analysis of HUVEC using 86010-2-RR (same clone as 86010-2-PBS)

  HUVEC cells were subjected to SDS PAGE followed by western blot with 86010-2-RR (TEK antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86010-2-PBS in a different storage buffer formulation.

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Informations sur le produit

86010-2-PBS cible Tie-2/CD202b dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Tie-2/CD202b Protéine recombinante Eg3367
• Nom complet: TEK tyrosine kinase, endothelial
• Masse moléculaire calculée: 1124 aa, 126 kDa
• Poids moléculaire observé: 120 kDa, 160 kDa
• Numéro d’acquisition GenBank: BC035514
• Symbole du gène: Tie2
• Identification du gène (NCBI): 7010
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Tie2 (also known as TEK) is a tyrosine-protein kinase expressed almost exclusively on endothelial cells. It contains two immunoglobulin-like domains, three epidermal growth factor (EGF)--like domains and three fibronectin type III repeats. Tie2 acts as a cell-surface receptor for ANGPT1, ANGPT2, and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Mutations in the gene Tie2 are associated with inherited venous malformations of the skin and mucous membranes. Human Tie2 has a calculated molecular weight of 126 kDa. As a result of glycosylation, the apparent molecular mass of Tie2 is approximately 140-160 kDa.

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