Anticorps Recombinant de lapin anti-Tie-2/CD202b

Tie-2/CD202b Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241753F12

N° de cat : 98219-1-RR

Synonymes

HYK, Endothelial tyrosine kinase, EC:2.7.10.1, CD202b, Angiopoietin-1 receptor

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Galerie de données de validation

• 

  FC experiment of bEnd.3 using 98219-1-RR

  1x10^6 bEnd.3 cells were surface stained with 0.25 ug Anti-Mouse Tie-2 Rabbit Recombinant Antibody (98219-1-RR, Clone:241753F12) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98219-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98219-1-RR against Mouse Tie-2/CD202b were performed. The affinity constant is below 1 pM.

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Applications testées

• Résultats positifs en cytométrie: cellules bEnd.3,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98219-1-RR cible Tie-2/CD202b dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: endothelial-specific receptor tyrosine kinase
• Masse moléculaire calculée: 126kDa
• Numéro d’acquisition GenBank: NM_001290549.1
• Symbole du gène: Tek
• Identification du gène (NCBI): 21687
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

Tie-2, also known as CD202b or TEK, is a receptor tyrosine kinase (RTK) specifically expressed in endothelial cells. It plays a crucial role in angiogenesis, forming new blood vessels, and maintaining vascular stability. Tie-2 is a member of the Tie receptor family, characterized by the presence of immunoglobulin and epidermal growth factor (EGF) homology domains. Tie-2 plays a significant role in several vascular diseases, including vascular malformations like venous malformations. It is also implicated in pathological vascular remodeling associated with tumor growth, where it is often overexpressed in tumor vessels.

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