Anticorps Recombinant de lapin anti-Tie-2/CD202b

Tie-2/CD202b Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250234B4

N° de cat : 98462-3-PBS

Synonymes

TEK, Angiopoietin 1 receptor, Angiopoietin-1 receptor, CD202B, EC:2.7.10.1

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Galerie de données de validation

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  FC experiment of HUVEC using 98462-3-RR (same clone as 98462-3-PBS)

  1x10^6 HUVEC cells (left) or 293T cells (right) were surface stained with 0.15 ug Anti-Human Tie-2/CD202b Rabbit RecAb (98462-3-RR, Clone: 250234B4) or 0.15 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L)(red). Cells were not fixed. This data was developed using the same antibody clone with 98462-3-PBS in a different storage buffer formulation.

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Informations sur le produit

98462-3-PBS cible Tie-2/CD202b dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Tie-2/CD202b Protéine recombinante Eg3367
• Nom complet: TEK tyrosine kinase, endothelial
• Masse moléculaire calculée: 1124 aa, 126 kDa
• Numéro d’acquisition GenBank: BC035514
• Symbole du gène: Tie2
• Identification du gène (NCBI): 7010
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Tie-2, also known as CD202b or TEK, is a receptor tyrosine kinase (RTK) specifically expressed in endothelial cells. It plays a crucial role in angiogenesis, forming new blood vessels, and maintaining vascular stability. Tie-2 is a member of the Tie receptor family, characterized by the presence of immunoglobulin and epidermal growth factor (EGF) homology domains. Tie-2 plays a significant role in several vascular diseases, including vascular malformations like venous malformations. It is also implicated in pathological vascular remodeling associated with tumor growth, where it is often overexpressed in tumor vessels.

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