Anticorps Polyclonal de lapin anti-Transferrin Receptor 2/TFR2

Transferrin Receptor 2/TFR2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32381-1-PBS

Synonymes

TFR2, Transferrin receptor protein 2, transferrin receptor 2, TFRC2, HFE3

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Galerie de données de validation

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  WB analysis using 32381-1-AP (same clone as 32381-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32381-1-AP (TFR2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32381-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse liver using 32381-1-AP (same clone as 32381-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 32381-1-AP (Transferrin Receptor 2/TFR2 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 32381-1-PBS in a different storage buffer formulation.

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Informations sur le produit

32381-1-PBS cible Transferrin Receptor 2/TFR2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Transferrin Receptor 2/TFR2 Protéine recombinante Ag37959
• Nom complet: transferrin receptor 2
• Masse moléculaire calculée: 801 aa, 89 kDa
• Poids moléculaire observé: 88-97 kDa
• Numéro d’acquisition GenBank: BC142630
• Symbole du gène: TFR2
• Identification du gène (NCBI): 7036
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Transferrin Receptor 2 (TFR2) is a type II transmembrane glycoprotein that plays a crucial role in iron homeostasis. It is highly homologous to Transferrin Receptor 1 (TFR1) and is primarily expressed in the liver and erythroid precursor cells. TFR2 is involved in the regulation of hepcidin, a hormone that controls iron absorption and distribution in the body. It helps mediate the cellular uptake of iron-bound transferrin, although its affinity for iron is lower than that of TFR1 (PMID: 24658816). It is more involved in sensing iron levels and regulating hepcidin expression rather than direct iron uptake. TFR2 is predominantly expressed in hepatocytes (liver cells) and erythroid precursors (cells that give rise to red blood cells). It is also found in the enterocytes of the small intestine (PMID: 29969719). In the liver, TFR2 acts as a sensor for circulating iron-bound transferrin and helps regulate hepcidin production. Hepcidin, in turn, controls iron absorption from the diet and iron release from macrophages. The molecular weight of TFR2 is 88 kDa, its observed molecular weight is 88-97 kDa.

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