Anticorps Polyclonal de lapin anti-UBFD1

UBFD1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32161-1-PBS

Synonymes

Ubiquitin-binding protein homolog, Ubiquitin Family Domain Containing 1 , Ubiquitin domain-containing protein UBFD1

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Galerie de données de validation

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  WB analysis using 32161-1-AP (same clone as 32161-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32161-1-AP (UBFD1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32161-1-PBS in a different storage buffer formulation.

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Informations sur le produit

32161-1-PBS cible UBFD1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: UBFD1 Protéine recombinante Ag36361
• Nom complet: ubiquitin family domain containing 1
• Masse moléculaire calculée: 309aa, 33 kDa
• Poids moléculaire observé: 40 kDa
• Numéro d’acquisition GenBank: NM_019116
• Symbole du gène: UBFD1
• Identification du gène (NCBI): 56061
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

UBFD1 (Ubiquitin Family Domain Containing 1) is a polyubiquitin-binding protein containing ubiquitin-like structural domains that are widely involved in protein degradation and cell signaling. This protein shows aberrant expression in a variety of cancers, especially in estrogen receptor (ER)-positive breast cancer, where high expression of UBFD1 is closely associated with poor prognosis of patients, and is considered as a potential prognostic biomarker and therapeutic target. In addition, UBFD1 was also found to be associated with MYC-mediated tumor aggressiveness in T-cell acute lymphoblastic leukemia (T-ALL), which functionally involves the endoplasmic reticulum-associated degradation (ERAD) pathway. UBFD1 is also expressed in inner ear hair cells and ear epithelial cells, suggesting that it may play a role in hearing-related diseases.

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